12th International Congress of TDM & Clinical Toxicology
Pharmacometrics Committee
Last update: November 6, 2012
(The Pharmacometrics Committee was formerly known as Clinical Pharmacokinetics Committee, Name changed December 2009. Committee merged with the Pharmacoeconomics Committee, May 2010)
Chair: Franck Saint-Marcoux, France franck.saint-marcoux@unilim.fr
Vice-chair: Paula Schaiquevich, Argentina
Background/purpose of the committee:
Pharmacometrics is the science of Quantitative Pharmacology that uses models based on pharmacology, physiology and disease for the quantitative analysis of interactions between drugs and patients. This involves pharmacokinetic (PK), pharmacodynamics (PD), pharmacogentics (PG), and disease progression with a focus on populations and variability.
Pharmacometricians are clinical scientists applying such mathematical and statistical methods to drug therapy with the aim of predicting the concentration time profile and total drug exposure (Area under the Curve, AUC) and its associations with physiologic effects and clinical outcomes.
In the clinical setting, Pharmacometrics aims at obtaining a better response with minimal adverse events in each individual.
The committee promotes:
- Communication between scientists of all disciplines involved in Pharmacometrics.
- Effective use of computer applications and their delivery at the clinical interface.
- The utilization of cost-effectiveness and cost-utility models to justify its use in daily patient care.
Activities of the committee:
To actively participate in national and international fora on therapeutic drug monitoring and clinical pharmacokinetics.
To develop methods for studying the cost-effectiveness of Therapeutic Drug Monitoring.
To develop ideas for committee activities.
Membership list (November 2012):
Alison Thomson, Benedetta Sallustio, Ehab el Desoky, Guillermo Bramugia, Ken Ilett, Kees Neef, Kimikazu Shinozaki, Li Wang, Michael Neely, Philip Patsalos, Guido Paolo Caceres, Pierre Marquet, Raman Venkat, Ray Morris, Roger Jelliffe, Samantha Carmichael, Sander Vinks, Shareen Cox, Zul Verjee, Iona MacDonald, Edgar Spencer, Reinier van Hest, Jeff Barrett, Duan Jingli, Hundie Tesfaye, Catherine Sherwin, Tsuyoshi Fukuda, Yoriko Harigaya, Jodi Courtney, Sal Salamone, Paula Schaiquevich, Franck Saint-Marcoux.
Report on activities:
During the meeting of the Committee on October 5, 2011, in Stuttgart, Franck Saint-Marcoux and Paula Shaiquevich have been elected as chairman and co-chairman, respectively.
It was discussed that within IATDMCT there is a call for webinars and members of the committee were asked to bring forward topics for these educational activities. The suggestion was made to prepare a teaching program that would cover the field of Pharmacometrics (ie, PK, PD ant their applications).
Paula Shaiquevich has been involved in the organization of a regional meeting in Argentina in November 2012. This meeting will focus on individualized pharmacotherapy integrating pharmacokinetics, pharmacodynamics and pharmacogenetics.
In collaboration with the Standard of Practice committee, the Pharmacometrics committee is involved in a project that aims at proposing guidelines to help ensure the quality of TDM practice. The first drug group targeted will be the immunosuppressive drugs. The first task of the Pharmacometrics committee is to provide with the published papers that focus on PK/PD of these compounds, ideally those describing the added-value of PK-based dose adjustment strategies.
The text of the committee’s webpage was updated according to its missions and membership.
Ideas were exchanged and a proposal was made for a workshop during the 2013 Meeting of IADMCT. The objectives of the workshop are to present and discuss advantages and limits of parametric and non parametric approaches when applied to clinical use to guide and adjust therapy. The experience of different centres will be presented.
Contribution of the committee for Compass: November 2012.
The following documents are available to IATDMCT members:
Report to the membership Annual Meeting
October 8, 2009, Montreal Quebec
Report to the membership Annual Meeting
September 14, 2007, Nice France
