Eight Drugs a Week, Episode 3 – TDM of Biologics

Created: Thursday, 02 March 2023 15:37

Last Updated: Thursday, 02 March 2023 15:38

Written by Jana Stojanova

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Our guests today are Annick de Vries and Murray Barclay, and both have made important contributions in the space. Once again, our guests coincided on their favourite Beatle – one that we haven’t heard mentioned in previous episodes!

In this episode we hear about:

• the differences between small molecule drugs and biologics, and the implications this has for TDM of the latter
• how disease severity may influence pharmacodynamics, and ultimately how we might ultimately select treatment targets despite challenges in obtaining measurements of disease activity
• anti-drug antibodies and the role of TDM there
• disease dependent clearance and whether concentrations of biologics might possibly be a marker of disease activity

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About our guests:

Annick is director of Diagnostic Services at Sanquin in Amsterdam, The Netherlands. Sanquin is a not-for-profit that provides blood products nationwide, but also develop specialized pharmaceutical products and provide diagnostic services. She is the current chair of the IATDMCT Biologics Committee.

Murray is a clinical pharmacologist and a gastroenterologist at Christchurch Hospital in New Zealand, and a Clinical Professor at the University of Otago. Murray was the previous chair of the Biologics Committee.