International Association of
Therapeutic Drug Monitoring and Clinical Toxicology
Fostering education, research and practice in TDM and CT

Anti-Infective Drugs Committee

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Chair

Debbie Marriott
Sydney, Australia

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Scientific Committees
Anti-Infective Drugs Committee

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Vice-Chair

Dario Cattaneo
Milan, Italy

Background & Purpose of the Committee

Over the past few years the field of TDM in infectious diseases has evolved. Based on this the scope of the Antifungal Drugs committee was expanded to Anti-Infective Drugs committee in 2011 (without antiretroviral drugs). During 2013, the HIV drugs committee proposed to have a joint Anti-Infective Drugs committee to preserve active members and broaden our interaction between colleagues. The proposal to join form a new larger Anti-Infective Drug committee (2013) was accepted with great enthusiasm. The previous experience of both committees will be beneficial, in particular the interplay with the multidisciplinary fields of Infectious Diseases.

Anti-Infective Drugs TDM is a challenging issue. The availability of LC (MS-MS) methods offers the potential to move from microbiological assays to physical-chemical procedures for the determination of these drugs in biological samples. It also provides multi-drug determination per run in a turnaround time that meets clinical relevance.

The purpose of the committee is to promote the clinical application of the TDM of anti-infective drug therapy and the development of laboratory assays for the determination of anti-infective drug concentrations in a variety of body fluids and tissues.

  • To promote the use of adequate analytical assays to quantify anti-infective drugs in biological matrices;
  • To develop and update guidelines for TDM based on current knowledge of target drug exposures and relevant biomarkers; and
  • To encourage professionals to apply TDM in the field of infectious diseases and to report their results to increase the level of evidence for TDM.

Major publication initiatives of the Anti-Infectives group

  1. TDM can improve linezolid dosing regimens in current clinical practice: a systematic review. Rao G, Konicki R, Cattaneo D, Marriott D, Neely M. Ther Drug Monit. 2019 Oct 23. doi: 10.1097/FTD.0000000000000710.
  2. How to design a study to evaluate therapeutic drug monitoring in infectious diseases? Märtson, A-G; Sturkenboom, M; Stojanova, J; Cattaneo, D; Hope, W; Marriott, D; Patanwala, A; Peloquin, C; Wicha, S; van der Werf, TS; Tängdén, T; Roberts, J; Neely, M; Alffenaar, J-W. Submitted to Clinical Microbiology and Infection.
  3. Impact of Therapeutic Drug Monitoring of Antiretroviral Drugs in Routine Clinical Management of People Living with HIV: a narrative review. Cattaneo D, Baldelli S, Cozzi V, Clementi E, Marriott DJ, Gervasoni C. Ther Drug Monit. 2019 Aug 5. doi: 10.1097/FTD.0000000000000684.

Scientific contributions

  • Members of the Anti-Infectives committee have over 100 publications in refereed journals in the last 12 months
  • Presentations at over 30 national and international conferences
  • 12 regular reviewers for peer-reviewed journals

Future activities

  • Regional Anti-Infectives TDM meeting – Singapore, November 3-4, 2020. This will be held immediately prior to the Asia-Pacific Conference on Clinical Microbiology and Infections, a well-respected conference attracting over 1000 delegates. It is anticipated that approximately 80 participants will attend. The ability to use speakers already invited to the APCCMI (Debbie Marriott, Jason Roberts, Jeff Lipman) will reduce costs to IATDMCT. The Singapore Infectious Diseases Society has generously offered to provide their conference organizing facilities for our regional meeting.
  • The possibility of a future regional meeting in India is being explored
  • The opportunity for affiliation with other societies is being actively examined
  • New social media team (Indy Sandaradura, Danijela Kocic) will liaise with the Chair of the Communications Committee to increase content from the Anti-Infectives group

ECCMID 2019 pre-conference workshop

  • Sold out within weeks of opening
  • Oversubscribed two-fold
  • Majority of speakers were members of IATDMCT

Sessions at IATDMCT ASM 2019

  • Clinical use of PK/PD for individualization of antibiotic therapy. Birgit Koch.
  • Anti-infective agents and therapeutic drug monitoring: the ultimate precision medicine when no two patients are alike. Danijela Kocic, Jan-Willem Alffenaar, Miao Yan.
  • Not just tuberculosis: the therapeutic challenge of acid-fast organisms. Deborah Marriott, Michael Neely, Jan-Willem Alffenaar
  • Oral presentation session

Committee Initiatives for 2016/2017

  • To publish a white paper on study design to evaluate TDM of anti-infective drugs
  • To publish TDM guidelines for ‘high priority’ anti-infective drugs
  • To have members participate in different (inter)national committees with a focus on TDM of anti-infective drugs

Committee Initiatives Completed in 2014/2015

  • This committee was established in 2013.
  • IATDMCT supported the “3rd Annual Individualized Therapeutic Approach Group”, Barcelona, Spain, May 8-9, 2014 with many talks on anti-infectives
  • Dr. Neely was a visiting scholar sponsored by IATDMCT to conduct workshops and presentations largely focused on vancomycin and voriconazole
    • “Population Modeling with Pmetrics”, Christian Medical College, Vellore, Tamil Nadu, India, July 21-24, 2014
    • “Parametric and nonparametric dose optimization. Which is the best approach?”, University of Antioquia, Medellín, Colombia, November 7, 2014
    • “Population Modeling with Pmetrics”, Feevale University, Novo Hamborgo, Brazil, November 10-11, 2014